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MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Developmental Epigenetics
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1576768
Primordial Germ Cells as a Potential Model for Understanding (Nutri)epigenetic -Metabolic interactions: A Mini Review
Provisionally accepted- 1 PBS Doctoral School, Bydgoszcz University of Science and Technology, Bydgoszcz, Pomeranian, Poland
- 2 Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Pomeranian, Poland
Primordial germ cells (PGCs) are the progenitors of gametes (sperm and eggs), making them crucial for understanding germline transmission and epigenetic modifications, which are critical for studying transgenerational effects of nutrition and metabolic diseases. This is particularly relevant given the growing evidence that environmental factors, such as diet, can influence metabolic disease risk across generations through modulating epigenetic mechanisms, as seen in both human and animal studies. The unique biological and experimental attributes make PGCs in the chicken embryo a potential model for exploring the complex interactions between nutrition, epigenetic inheritance, and metabolic diseases, providing insights that are translatable to metabolic health and disease prevention tactics. This brief review emphasizes the potential of chicken PGCs as a model system to investigate the mechanisms underlying transgenerational metabolic programming.
Keywords: Nutritional programming, Nutriepigenetic, Metabolic processes, PGCs, transgenerational effects
Received: 14 Feb 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Ibrahim, Grochowska and Stadnicka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Katarzyna Stadnicka, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, 85-016, Pomeranian, Poland
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