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REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Death and Survival
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1562344
This article is part of the Research TopicCell Death Mechanisms in Neurodegenerative DisordersView all 5 articles
Oxidative Cell Death in the Central Nervous System: Mechanisms and Therapeutic Strategies
Provisionally accepted- 1First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
- 2Jilin Qianwei Hospital, Changchun, China
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Oxidative cell death is caused by an overproduction of reactive oxygen species (ROS) and an imbalance in the antioxidant defense system, leading to neuronal dysfunction and death. The harm of oxidative stress in the central nervous system (CNS) is extensive and complex, involving a variety of molecular and cellular level changes that may lead to a variety of acute and chronic brain pathologies, such as stroke, traumatic brain injury, or neurodegenerative diseases and psychological disorders. This review provides an in-depth look at the mechanisms of oxidative cell death in the CNS diseases. In addition, the review evaluated existing treatment strategies, including antioxidant therapy, gene therapy, and pharmacological interventions targeting specific signaling pathways, all aimed at alleviating oxidative stress and protecting nerve cells.We also discuss current advances and challenges in clinical trials, and suggest new directions for future research, including biomarker discovery, identification of potential drug targets, and exploration of new therapeutic techniques, with a view to providing more effective strategies for the treatment of CNS diseases.
Keywords: Oxidative Stress, Central Nervous System, Neurodegenerative Diseases, antioxidant therapy, Neuroprotection
Received: 17 Jan 2025; Accepted: 15 Apr 2025.
Copyright: © 2025 Liu, Liu, Wang, Feng, Piao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ming Liu, Jilin Qianwei Hospital, Changchun, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.