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REVIEW article

Front. Cell Dev. Biol.

Sec. Cellular Biochemistry

Volume 13 - 2025 | doi: 10.3389/fcell.2025.1553683

ANXA5: related mechanisms of osteogenesis and additional biological functions

Provisionally accepted
  • 1 Zhongshan College, Dalian University, Dalian, Liaoning Province, China
  • 2 National and Local Joint Engineering Laboratory for Orthopedic Implant Material Development, Affiliated Zhongshan Hospital of Dalian University, Dalian, China

The final, formatted version of the article will be published soon.

    Annexin A5 ( ANXA5 ) , also known as Annexin V, is a calcium-dependent phospholipidbinding protein and has a high affinity with phosphatidylserine(PS). This characteristic facilitates its involvement in a wide range of biological functions, including vesicle transport, the formation of mineral phases in the extracellular matrix, anticoagulation and antithrombotic, the inhibition of tumor growth, and apoptosis regulation. ANXA5 plays a role in anti-inflammatory and antithrombotic properties. It also has protective effects on the nervous system. ANXA5 has been reported to facilitate osteogenic differentiation and take part in chondrocyte apoptosis and mineralization. More and more attention is paid to the potential of ANXA5 for bone defect repair. Most current studies on ANXA5 mainly concentrate on immune disorders, pregnancy disorders and serve as a biomarker for various diseases as well as apoptosis detection. However, there is still a lack of systematic studies on ANXA5 involving multiple tissues, including bone, cartilage, vessels, and nerves in the process of bone regeneration. Our study aims to summarize the biological functions in bone tissue and the related signaling pathways of ANXA5. This work provides a theoretical foundation for applying ANXA5 in clinical orthopedics in the future.

    Keywords: Anxa5, phosphatidylserine, Bone Regeneration, biological functions, Signaling Pathways

    Received: 31 Dec 2024; Accepted: 31 Mar 2025.

    Copyright: © 2025 Jin, Zhang, Liu, Sun and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaowei Wei, National and Local Joint Engineering Laboratory for Orthopedic Implant Material Development, Affiliated Zhongshan Hospital of Dalian University, Dalian, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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