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ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1552727
This article is part of the Research Topic Application of Stem Cells in Degenerative Orthopedic Diseases View all articles
Bibliometric and Visualized Analysis of the Applications of Exosomes for Bone Regeneration
Provisionally accepted
Shuai Ai 1
Zhou Xie 1
Ningdao Li 1
Runhan Zhao 1
Xiao Qu 1
Haining Zhou 1 Dagang Tang 1* Jun Zhang 1*
Xiaoji Luo 2*- 1 1 Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University. Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine. Orthopaedic Research Laboratory of Chongqing Medical University., Chongqing Medical University, Chongqing, China
- 2 1 Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University. Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine. Orthopaedic Research Laboratory of Chongqing Medical University. 2 The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, 400060, People's Republic of China., Chongqing Medical University, Chongqing, China
Background: Bone defect, a common orthopedic condition, is characterized by a lengthy and impactful treatment period, posing a considerable challenge in clinical settings. Medical technology has advanced notably, and has effectively treated an increasing number of patients with bone defects. Consequently, there has been an explosion of research articles on bone regeneration, including a substantial number on the application of exosomes. Exosomes, especially those derived from stem cells, have been confirmed to be effective in bone regeneration and have garnered widespread attention in the last decade. Therefore, this study conducted a bibliometric analysis on publications related to the application of exosomes for bone regeneration. The objectives are to explore the development history and research hotspots in this field over the past ten years, predict future development trends, and provide guidance for subsequent research.
Keywords: Exosomes, Stem Cells, Osteogenesis, Bone Regeneration, Bibliometrics
Received: 29 Dec 2024; Accepted: 20 Feb 2025.
Copyright: © 2025 Ai, Xie, Li, Zhao, Qu, Zhou, Tang, Zhang and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dagang Tang, 1 Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University. Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine. Orthopaedic Research Laboratory of Chongqing Medical University., Chongqing Medical University, Chongqing, China
Jun Zhang, 1 Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University. Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine. Orthopaedic Research Laboratory of Chongqing Medical University., Chongqing Medical University, Chongqing, China
Xiaoji Luo, 1 Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University. Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine. Orthopaedic Research Laboratory of Chongqing Medical University. 2 The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, 400060, People's Republic of China., Chongqing Medical University, Chongqing, China
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