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REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1544310
Non-Coding RNAs as Key Regulators of Epithelial-Mesenchymal Transition in Breast Cancer
Provisionally accepted- 1 Lanzhou University Medical College, Lanzhou, Gansu, China
- 2 School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China
- 3 First Hospital of Lanzhou University, Lanzhou, China
This study examines the critical role of non-coding RNAs (ncRNAs) in regulating epithelial-mesenchymal transition (EMT) in breast cancer, a prevalent malignancy with significant metastatic potential. EMT, wherein cancer cells acquire mesenchymal traits, is fundamental to metastasis. ncRNAs-such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs)-modulate EMT by influencing gene expression and signaling pathways, affecting cancer cell migration and invasion. This review consolidates recent findings on ncRNA-mediated EMT regulation and explores their diagnostic and therapeutic potential. Specifically, miRNAs inhibit EMT-related transcription factors, while lncRNAs and circRNAs regulate gene expression through interactions with miRNAs, impacting EMT progression. Given the influence of ncRNAs on metastasis and therapeutic resistance,
Keywords: breast cancer, Epithelial-Mesenchymal Transition, noncoding RNAs, miRNAs, CircRNAs, lncRNAs, diagnostic biomarkers, therapeutic targets
Received: 13 Dec 2024; Accepted: 06 Mar 2025.
Copyright: © 2025 Peng, Liu, Tian, Shu, Zhao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuping Wang, First Hospital of Lanzhou University, Lanzhou, China
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