94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1542967
Notch signaling in cancers: Mechanism and potential therapy
Provisionally accepted- 1 Zhengzhou University of Light Industry, Zhengzhou, China
- 2 Henan University of Technology, Zhengzhou, Henan Province, China
The Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is pervasive in the human body, affecting tumorigenesis and progression, which is one of the most significant signaling pathways in this regard, influencing various receptors and cellular functions of tumor cells. Aberrant expression or mutation of Notch has been linked to the onset and progression of a variety of malignant tumors. In this review, we discussed the mechanism of Notch signaling in lung, liver and colorectal cancer and explored future strategies and directions for cancer treatment by modifying the Notch signaling pathway.
Keywords: Notch signaling, Cancer, Mechanism, mutations, potential therapy
Received: 10 Dec 2024; Accepted: 06 Feb 2025.
Copyright: © 2025 Chen, Du, Nie, Wang, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yan Du, Henan University of Technology, Zhengzhou, 450001, Henan Province, China
Rongzu Nie, Zhengzhou University of Light Industry, Zhengzhou, China
Shuangshuang Wang, Zhengzhou University of Light Industry, Zhengzhou, China
Peifeng Li, Zhengzhou University of Light Industry, Zhengzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.