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REVIEW article
Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 13 - 2025 |
doi: 10.3389/fcell.2025.1535249
Research Progress on Small Extracellular Vesicles in Diabetic Nephropathy
Provisionally accepted
Bingqing Yu 1,2
Lanfeng Wang 3*
Yiping Mao 1,2
Xinyi Hu 1,2
Yukang Lu 1,4 Jiahui He 1,2* Zhiping Chen 1,2*- 1 Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China, Ganzhou, Jiangxi Province, China
- 2 College of Medical Technology, Gannan Medical University, Ganzhou City, Jiangxi Province, China, Ganzhou, China
- 3 Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China, Ganzhou, Jiangxi Province, China
- 4 The First School of Clinical Medicine, Gannan Medical University, Ganzhou, Jiangxi Province, China
Virtually all cell types are capable of secreting small extracellular vesicles (sEV), which can be internalized by recipient cells, thereby serving as vehicles for intercellular communication. The cargoes of these vesicles, such as microRNAs, circular RNAs, proteins, and lipids, play significant roles in both normal cellular functions and the pathogenesis of various diseases. Diabetic Nephropathy (DN), a complication arising from diabetes, is expected to contribute to a 54% increase in the global diabetic population between 2015 and 2030, leading to substantial economic burdens on individuals and healthcare systems. sEVs, as promising biomarkers, demonstrate diverse mechanistic responses in different types of Diabetic Kidney Disease (DKD). They also hold advantages in the early prediction of renal damage. This article reviews the functional mechanisms of sEVs in DKD and their potential as therapeutic targets and biomarkers.
Keywords: diabetic nephropathy, Small extracellular vesicles, therapy, biomarkers, progress
Received: 27 Nov 2024; Accepted: 06 Feb 2025.
Copyright: © 2025 Yu, Wang, Mao, Hu, Lu, He and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lanfeng Wang, Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China, Ganzhou, Jiangxi Province, China
Jiahui He, Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China, Ganzhou, Jiangxi Province, China
Zhiping Chen, Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China, Ganzhou, Jiangxi Province, China
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