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REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Death and Survival
Volume 13 - 2025 |
doi: 10.3389/fcell.2025.1525073
The Critical Role of TRIM Protein Family in Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Perspectives
Provisionally accepted- 1 Department of Orthopedics, The Second Affliated Hospital (Changzheng Hospital), Naval Medical University, Shanghai, China
- 2 Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Naval Medical University, Shanghai, China
- 3 Department of Pharmacy, The First Affiliated Hospital (Changhai Hospital), Navy Medical University, Shanghai, China
Intervertebral disc degeneration (IVDD) is a leading cause of chronic back pain, contributing significantly to reduced quality of life and global public health burdens. The TRIM (Tripartite Motif-containing) protein family, with its diverse regulatory roles, has emerged as a key player in critical cellular processes such as inflammation, cell death, and extracellular matrix (ECM) metabolism. Recent findings underscore the involvement of TRIM proteins in IVDD pathogenesis, where they regulate stress responses, maintain cellular homeostasis, and influence the functional integrity of nucleus pulposus (NP) and annulus fibrosus (AF) cells. This review explores the multifaceted roles of TRIM proteins in IVDD, highlighting their contributions to pathological pathways and their potential as therapeutic targets. Advancing our understanding of TRIM protein-mediated mechanisms may pave the way for innovative and precise therapeutic strategies to combat IVDD.
Keywords: Intervertebral Disc Degeneration, TRIM protein family, Cell Death, Inflammation, Extracellular Matrix Metabolism IVDD
Received: 08 Nov 2024; Accepted: 20 Jan 2025.
Copyright: © 2025 Li, Jiang, Chen, Qian and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fei Chen, Department of Orthopedics, The Second Affliated Hospital (Changzheng Hospital), Naval Medical University, Shanghai, China
Jiao Qian, Department of Pharmacy, The First Affiliated Hospital (Changhai Hospital), Navy Medical University, Shanghai, China
Jun Yang, Department of Orthopedics, The Second Affliated Hospital (Changzheng Hospital), Naval Medical University, Shanghai, China
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