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REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1489958
Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression
Provisionally accepted- Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in a variety of cell types and are involved in multiple physiological regulatory mechanisms in cells, tissues and systems.Increasing evidence suggests that the α5 nicotinic acetylcholine receptor (α5-nAChR), encoded by the CHRNA5 gene, is one of a key mediator involved in lung cancer development and immune responses. Several studies have shown that it is a regulator that stimulates processes via various signaling pathways, including STAT3 in lung cancer. In addition, α5-nAChR has a profound effect on lung immune response through multiple immune-related factor pathways. In this review, we focus on the perspectives on α5-nAChR in lung cancer progression, which indicates that targeting α5-nAChR could provide novel anticancer and immune therapy strategies for lung cancer.
Keywords: α5-nAChR, Growth, Epithelial mesenchymal transition (EMT), immune escape, lung cancer
Received: 02 Sep 2024; Accepted: 26 Feb 2025.
Copyright: © 2025 Jiaying, Jingting, Zengping, Jing, Jia and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoli Ma, Central Hospital Affiliated to Shandong First Medical University, Jinan, 271000, Shandong Province, China
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