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REVIEW article

Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1485422

Investigating the Role of Exosomal Long Non-Coding RNAs in Drug Resistance within Female Reproductive System Cancers

Provisionally accepted
Nooshafarin Shirani Nooshafarin Shirani 1Neda Abdi Neda Abdi 1Matin Chehelgerdi Matin Chehelgerdi 2Hajar Yaghoobi Hajar Yaghoobi 1*Mohammad Chehelgerdi Mohammad Chehelgerdi 2
  • 1 Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  • 2 Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University,, Sahrekord, Iran

The final, formatted version of the article will be published soon.

    Exosomes, as key mediators of intercellular communication, have been increasingly recognized for their role in the oncogenic processes, particularly in facilitating drug resistance. This article delves into the emerging evidence linking exosomal lncRNAs to the modulation of drug resistance mechanisms in cancers such as ovarian, cervical, and endometrial cancer. It synthesizes current research findings on how these lncRNAs influence cancer cell survival, tumor microenvironment, and the efficacy of chemotherapy.Additionally, the review highlights potential therapeutic strategies targeting exosomal lncRNAs, proposing a new frontier in overcoming drug resistance. By mapping the interface of exosomal lncRNAs and drug resistance, this article aims to provide a comprehensive understanding that could pave the way for innovative treatments and improved patient outcomes in female reproductive system cancers.

    Keywords: Exosomes, long non-coding RNAs, Drug Resistance, Female Reproductive System Cancers, Tumor Microenvironment, Chemotherapy efficacy, targeted therapies

    Received: 23 Aug 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Shirani, Abdi, Chehelgerdi, Yaghoobi and Chehelgerdi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hajar Yaghoobi, Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.