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REVIEW article
Front. Cell Dev. Biol.
Sec. Epigenomics and Epigenetics
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1453624
This article is part of the Research TopicAging, Cellular Senescence in Bone and Joint DiseasesView all 5 articles
Regulation of protein arginine methyltransferase in osteoporosis: a narrative review
Provisionally accepted- Shenyang Sport University, Shenyang, Liaoning Province, China
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Osteoporosis (OP), a systemic bone disease characterised by increased bone fragility and susceptibility to fracture, is mainly caused by a decline in bone mineral density (BMD) and quality caused by an imbalance between bone formation and resorption. Protein arginine methyltransferases (PRMTs) are epigenetic factors and post-translational modification (PTM) enzymes participating in various biological processes, including mRNA splicing, DNA damage repair, transcriptional regulation, and cell signalling. They act by catalysing the transfer and modification of arginine residues and, thus, have become therapeutic targets for OP. In-depth studies have found that these enzymes also play key roles in bone matrix protein metabolism, skeletal cell proliferation and differentiation, and signal pathway regulation to regulate bone formation, bone resorption balance, or both and jointly maintain bone health and stability. However, the expression changes and mechanisms of action of multiple members of the PRMT family differ in OP. Therefore, this paper discusses the biological functions, mechanisms of action, and influencing factors of PRMTs in OP, which is expected to provide a new understanding of the pathogenesis of OP. Furthermore, we present theoretical support for the development of more precise and effective treatment strategies as well as for further study of the molecular mechanisms of PRMTs.
Keywords: protein arginine transferase, Osteoporosis, Bone formation, Bone Resorption, osteoclast, osteoblast
Received: 24 Jun 2024; Accepted: 14 Apr 2025.
Copyright: © 2025 Wen, Huang, Yang, Yang and Yi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xuejie Yi, Shenyang Sport University, Shenyang, Liaoning Province, China
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