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PERSPECTIVE article

Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1526635
This article is part of the Research Topic Induced Pluripotent Stem Cells (iPSCs) for Skeletal Muscle Diseases View all 5 articles

Multitasking Muscle: Engineering iPSC-derived Myogenic Progenitors to do More

Provisionally accepted
Mark Stephen Hamer Mark Stephen Hamer Fabio Rossi Fabio Rossi *
  • University of British Columbia, Vancouver, Canada

The final, formatted version of the article will be published soon.

    The generation of myogenic progenitors from iPSCs (iMPs) with therapeutic potential for in vivo tissue regeneration has long been a goal in the skeletal muscle community. Today, protocols enable the production of potent, albeit immature, iMPs that resemble Pax7+ adult muscle stem cells. While muscular dystrophies are often the primary therapeutic target for these cells, an underexplored application is their use in treating traumatic muscle injuries. Notably absent from recent reviews on iMPs is the concept of engineering these cells to perform functions posttransplantation that non-transgenic cells cannot. Here, we highlight protocols to enhance the generation, purification, and maturation of iMPs, and introduce the idea of engineering these cells to perform functions beyond their normal capacities, envisioning novel therapeutic applications.

    Keywords: Myogenic progenitor cells, muscle regeneration, cell therapeutic, Synthetic biology (synbio), muscle stem cell (MuSC), IPSCs (induced pluripotent stem cells)

    Received: 12 Nov 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Hamer and Rossi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fabio Rossi, University of British Columbia, Vancouver, Canada

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.