Futoshi Suizu ^*

• Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Takamatsu, Japan

underlying PIN1-mediated signaling pathways and explores the therapeutic implications of targeting PIN1 in disease intervention.We begin with original research articles that unveil novel insights into PIN1 biology and its implications for disease pathology and treatment. The development of a contacting transwell co-culture system for the in vitro propagation of primary central nervous system lymphoma offers a valuable tool for studying this aggressive malignancy and investigating potential Collectively, the articles in this volume contribute to our growing understanding of the intricate roles of PIN1 in cellular physiology and pathology. As we navigate through the complexities of PIN1 biology, it becomes increasingly clear that a multidisciplinary approach is essential to fully comprehend its diverse roles in health and disease. By integrating knowledge from fields such as biochemistry, structural biology, cell biology, and medicine, we can gain a more comprehensive understanding of PIN1 function and its implications for human health. We extend our sincere appreciation to the authors for their outstanding contributions and to the readers for their interest in this topic. Together, let us continue to unravel the complexities of phosphorylation-dependent peptidyl-prolyl cis/trans isomerase PIN1 and explore its therapeutic potential for improving human health and well-being.Keywords: PIN1, phosphorylation, peptidyl-prolyl isomerization, PIN1 inhibitor, cancer, Alzheimer's disease, viral infection, tau, dementia Futoshi SuizuEditorial Team