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MINI REVIEW article

Front. Cell Dev. Biol.
Sec. Signaling
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1517181

Cross-talk of Renal Cells through WNT Signal Transduction in the Development of Fibrotic Kidneys

Provisionally accepted
Chen Yuhong Chen Yuhong *Chao Xue Chao Xue *
  • Department of Nephrology, Second Affiliated Hospital of Guangxi Medical University, Nanning, China

The final, formatted version of the article will be published soon.

    Chronic kidney disease (CKD) is a progressive condition that can lead to chronic renal failure (CRF), affecting 8-16% of adults globally and imposing a significant burden on healthcare systems. Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multiple signaling pathways, including WNT/β-catenin.Aberrant activation of WNT/β-catenin is implicated in renal fibrosis. The roles of renal macrophages and fibroblasts are pivotal in fibrosis progression and prognosis.

    Keywords: Cross-talk, kidney fibrosis, Wnt/β- catenin signaling, macrophage, fibroblast

    Received: 25 Oct 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Yuhong and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chen Yuhong, Department of Nephrology, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
    Chao Xue, Department of Nephrology, Second Affiliated Hospital of Guangxi Medical University, Nanning, China

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