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REVIEW article
Front. Cell Dev. Biol.
Sec. Signaling
Volume 12 - 2024 |
doi: 10.3389/fcell.2024.1516613
Portrait of WWP1: the current state in human cancer
Provisionally accepted
Jiaming Lei
1
Jun Chen
2
Wenwen Yu
1
Qing Wu
3
Shuang Jing
1
Yuanguang Tang
1
Li Lin
1*
Meichun Hu
1*- 1 Hubei University of Science and Technology, Xianning, China
- 2 Ezhou Central Hospital, Ezhou, Hubei Province, China
- 3 Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan Province, China
WWP1, a member of the C2-WW-HECT E3 ligase family, is an E3 ubiquitinprotein ligase containing WW domains. This enzyme is crucialplays a critical role in regulating variousdiverse cellular processes. Its expression is influencedmodulated by multiplevarious factors and non-coding RNAs, leading toresulting in ubiquitination that modulatesaffects substrate protein degradation. WWP1 exhibitsdemonstrates a dual rolefunction, acting predominantly as an oncogene in most tumors whilebut occasionally serving as a tumor suppressor. This review intends to summarizesummarizes WWP1's biological functions androles, therapeutic potential in oncology, along with its upstream regulatory factors, and downstream substrates. It aims to advancepromote research on WWP1'sWWP1's antitumor effects, enhancingimprove understanding of its involvementrole in tumorigenesis, and aidingsupport the development of targeted therapies.
Keywords: WWP1, Human cancer, Upstream factor, Downstream substrate, targeted therapy
Received: 24 Oct 2024; Accepted: 31 Dec 2024.
Copyright: © 2024 Lei, Chen, Yu, Wu, Jing, Tang, Lin and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Li Lin, Hubei University of Science and Technology, Xianning, China
Meichun Hu, Hubei University of Science and Technology, Xianning, China
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