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REVIEW article

Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1513426

Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: A comprehensive review

Provisionally accepted
Weihong Kuang Weihong Kuang Jialin Xu Jialin Xu Fenting Xu Fenting Xu Weizhen Huang Weizhen Huang Muhammad Majid Muhammad Majid Hui Shi Hui Shi Xia Yuan Xia Yuan Yongdui Ruan Yongdui Ruan Xianjing Hu Xianjing Hu *
  • Guangdong Medical University, Dongguan, China

The final, formatted version of the article will be published soon.

    Chronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa's cascade, CAG is an important pathological stage in the transformation from normal condition to gastric carcinoma. In recent years, the global incidence of CAG has been increasing due to pathogenic factors, including Helicobacter pylori infection, bile reflux, and the consumption of processed meats. In this review, we comprehensively described the etiology and clinical diagnosis of CAG. We focused on elucidating the regulatory mechanisms and promising therapeutic targets in CAG, with the expectation of providing insights and theoretical support for future research on CAG.

    Keywords: Chronic atrophic gastritis, pathogenetic mechanisms, Gastric precancerous lesions, biomarkers, therapeutic targets

    Received: 18 Oct 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Kuang, Xu, Xu, Huang, Majid, Shi, Yuan, Ruan and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xianjing Hu, Guangdong Medical University, Dongguan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.