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REVIEW article

Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1512988
This article is part of the Research Topic From Eye to Brain: Clinical and Pathological Implications of Ocular Disorders View all articles

Retinal glia in myopia: current understanding and future directions

Provisionally accepted
Pengfan Chen Pengfan Chen 1Jing Ji Jing Ji 1Xinyi Chen Xinyi Chen 2Jiali Zhang Jiali Zhang 1Xiangyi Wen Xiangyi Wen 1*Longqian Liu Longqian Liu 1*
  • 1 Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China
  • 2 West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Myopia, a major public health problem, involves axial elongation and thinning of all layers of the eye, including sclera, choroid and retina, which defocuses incoming light and thereby blurs vision. How the various populations of glia in the retina are involved in the disorder is unclear. Astrocytes and Müller cells provide structural support to the retina. Astrogliosis in myopia may influence blood oxygen supply, neuronal function, and axon diameter, which in turn may affect signal conduction. Müller cells act as a sensor of mechanical stretching in myopia and trigger downstream molecular responses. Microglia, for their part, may exhibit a reactive morphology and elevated response to inflammation in myopia. This review assesses current knowledge about how myopia may involve retinal glia, and it explores directions for future research into that question.

    Keywords: Myopia, Retina, glia, astrocyte, Müller cells, Microglia

    Received: 17 Oct 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Chen, Ji, Chen, Zhang, Wen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiangyi Wen, Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China
    Longqian Liu, Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.