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REVIEW article

Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1505601
This article is part of the Research Topic Stem Cell Research and Therapy for Liver and Kidney Diseases View all articles

Cell Therapy in Kidney Diseases: Advancing Treatments for Renal Regeneration

Provisionally accepted
Amankeldi A. Salybekov Amankeldi A. Salybekov 1,2*Aiman Kinzhebay Aiman Kinzhebay 1Shuzo Kobayashi Shuzo Kobayashi 2
  • 1 Qazaq Institute of Innovative Medicine, Astana, Kazakhstan
  • 2 Shonan Kamakura General Hospital, Kamakura, Japan

The final, formatted version of the article will be published soon.

    Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), pose a significant global health challenge, with high morbidity and mortality rates driven by rising prevalence of risk factors such as diabetes and hypertension. Current therapeutic strategies are often limited, prompting the exploration of advanced cell therapies as potential solutions. This review provides a comprehensive overview of the state of cell therapies in kidney disease, tracing the progression from preclinical studies to clinical applications. Recent studies highlited that cellbased interventions offer kidney-protective properties through mechanisms such as paracrine signaling, immune modulation, and direct tissue integration, demonstrating potential in both AKI and CKD settings. Despite promising results, challenges remain in optimizing cell therapy protocols, including cell sourcing, delivery methods, and long-term outcomes. Finally, the review addresses on efforts to enhance cell function, optimize dosing, and refine delivery techniques to improve clinical outcomes in kidney disease management.

    Keywords: cell therapy, chronic kidney diseases, Acute Kidney Injury, Kidney Diseases, Mesenchimal Stem Cells, CD34 cells

    Received: 03 Oct 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Salybekov, Kinzhebay and Kobayashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Amankeldi A. Salybekov, Qazaq Institute of Innovative Medicine, Astana, Kazakhstan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.