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REVIEW article

Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1492821

Mesenchymal stem cell-derived extracellular vesicles in systemic sclerosis: role and therapeutic directions

Provisionally accepted
Xuan Wang Xuan Wang Jiaying Guo Jiaying Guo *Qiangfu Dai Qiangfu Dai *
  • Second Affiliated Hospital of Wannan Medical College, Wuhu, China

The final, formatted version of the article will be published soon.

    Systemic sclerosis (SSc) is a complex autoimmune disease with clinical symptoms of vascular damage, immune disorders, and fibrosis, presenting significant treatment challenges and limited therapeutic options. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been demonstrated in numerous studies as more effective than MSCs in treating autoimmune diseases. Recent studies demonstrate that MSC-EVs can significantly ameliorate the symptoms of SSc and mitigate pathological changes such as vascular injury, immune dysregulation, and fibrosis. These findings underscore the promising therapeutic potential of MSC-EVs in the treatment of SSc. MSC-EVs promote angiogenesis, modulate immune dysfunction, and combat fibrosis. This article summarizes the therapeutic applications and possible mechanisms of MSC-EVs for SSc, thereby offering a novel therapeutic direction for the treatment of SSc.

    Keywords: systemic sclerosis, extracellular vesicles, Mesenchymal Stem Cells, Fibrosis, autoimmune disease

    Received: 08 Sep 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Wang, Guo and Dai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiaying Guo, Second Affiliated Hospital of Wannan Medical College, Wuhu, China
    Qiangfu Dai, Second Affiliated Hospital of Wannan Medical College, Wuhu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.