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ORIGINAL RESEARCH article

Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1491740
This article is part of the Research Topic Advancements in Molecular and Cellular Mechanisms of Stem Cells in Tissue Development and Regeneration View all articles

Kaempferol Enhances Intestinal Repair and Inhibits the Hyperproliferation of Aging Intestinal Stem Cells in Drosophila

Provisionally accepted
liusha Zhao liusha Zhao 1Ting Luo Ting Luo 1Hong Zhang Hong Zhang 2,3,4Xinxin Fan Xinxin Fan 5Qiaoqiao Zhang Qiaoqiao Zhang 6Haiyang Chen Haiyang Chen 1*
  • 1 Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 2 Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 3 Center for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 4 Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Shanxi Province, China
  • 5 Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University., Chengdu ,Sichuan, China
  • 6 Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Intestinal stem cells (ISCs) are crucial for tissue repair and homeostasis because of their ability to self-renew and differentiate. However, as organisms age, ISC function diminishes, impairing tissue regeneration, weakening intestinal barrier integrity, and heightened disease susceptibility. Therefore, improving ISC function during injury and aging is vital for enhancing tissue repair and maintaining overall homeostasis in tissues and organs. Kaempferol, a flavonoid abundant in various fruits and vegetables, is well-regarded for its antioxidant, anti-inflammatory, and potential anticancer effects. Although its impacts on ISCs and the associated mechanisms remain inadequately understood. Drosophila, with its mammalian-like intestinal system and extensively studied ISC lineage, is recognized as an ideal model for ISC research. Our findings indicate that Kaempferol accelerates gut recovery after damage and improves the organism's stress tolerance. Moreover, Kaempferol suppresses the hyperproliferation of aging ISCs in Drosophila. Further investigation revealed that the regulatory effects of Kaempferol on ISCs are mediated through the reduction of endoplasmic reticulum (ER) stress in aging flies and the modulation of excessive reactive oxygen species (ROS) levels via ER-stress pathways. Furthermore, Kaempferol exerts regulatory effects on the insulin signaling pathway, thereby contributing to the attenuation of ISC senescence.

    Keywords: Kaempferol, intestinal stem cell, ROS, Drosophila, Aging

    Received: 05 Sep 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Zhao, Luo, Zhang, Fan, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Haiyang Chen, Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.