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REVIEW article

Front. Cell Dev. Biol.
Sec. Embryonic Development
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1491394

Role of Spindle Assembly Checkpoint Proteins in Gametogenesis and Embryogenesis

Provisionally accepted
Brian J. North Brian J. North 1,2*Renju Pun Renju Pun 2
  • 1 Creighton University, Omaha, United States
  • 2 Biomedical Sciences, School of Medicine, Creighton University, Omaha, Nebraska, United States

The final, formatted version of the article will be published soon.

    The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents uneven segregation of sister chromatids between daughter cells during anaphase. This essential regulatory checkpoint prevents aneuploidy which can lead to various congenital defects observed in newborns. Many studies have been carried out to elucidate the role of proteins involved in the SAC as well as the function of the checkpoint during gametogenesis and embryogenesis. In this review, we discuss the role of SAC proteins in regulating both meiotic and mitotic cell division along with several factors that influence the SAC strength in various species. Finally, we outline the role of SAC proteins and the consequences of their absence or insufficiency on proper gametogenesis and embryogenesis in vivo.

    Keywords: spindle assembly checkpoint, Embryogenesis, Gametogenesis, Mitotic checkpoint, Mitosis

    Received: 04 Sep 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 North and Pun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Brian J. North, Creighton University, Omaha, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.