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MINI REVIEW article

Front. Cell Dev. Biol.
Sec. Signaling
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1485725
This article is part of the Research Topic Guanine Nucleotide Exchange Factors as Determinants of Cell Fate and Development View all 4 articles

Roles of the Dbl family of RhoGEFs in mechanotransduction -A review

Provisionally accepted
Kazumasa Ohashi Kazumasa Ohashi *Aoi Kunitomi Aoi Kunitomi Shuhei Chiba Shuhei Chiba Kensaku Mizuno Kensaku Mizuno
  • Tohoku University, Sendai, Japan

The final, formatted version of the article will be published soon.

    Rho guanine nucleotide exchange factors (RhoGEFs) comprise a wide range of proteins with a common domain responsible for the activation of the Rho family of small GTPases and various domains in other regions. The evolutionary divergence of RhoGEFs enables actin cytoskeletal reorganization, leading to complex cellular responses in higher organisms. In this review, we address the involvement of RhoGEFs in the mechanical stress response of mammalian cells. The cellular mechanical stress response is essential for the proper and orderly regulation of cell populations, including the maintenance of homeostasis, tissue morphogenesis, and adaptation to the mechanical environment. In particular, this review focuses on the recent findings regarding the Dbl family of RhoGEFs involved in mechanical stress responses at the cell-cell and cell-substrate adhesion sites, and their molecular mechanisms underlying actin cytoskeleton remodeling and signal transduction.

    Keywords: RhoGEF, Dbl family, Rho, Mechanotransduction, Actin Cytoskeleton

    Received: 24 Aug 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Ohashi, Kunitomi, Chiba and Mizuno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kazumasa Ohashi, Tohoku University, Sendai, Japan

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