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REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Growth and Division
Volume 12 - 2024 |
doi: 10.3389/fcell.2024.1483843
This article is part of the Research Topic Rehabilitation and Regeneration in Orthopaedic: From Cellular Regulation to Innovative Medical Technologies View all 4 articles
Recent advances in the regulatory and non-coding RNA biology of osteogenic differentiation: biological functions and significance for bone healing
Provisionally accepted
Samaris Aranguren
Hisae Cole
Lauren Jeannette Dargan
Madison Sarlo
Sumin Choi
Isha Satapathy
Jaira Ferreira de Vasconcellos
*- James Madison University, Harrisonburg, United States
Injuries associated with contemporary life, such as automobile crashes and sports injuries, can lead to large numbers of traumatic neuromuscular injuries that are intimately associated with bone fractures. Regulatory and non-coding RNAs play essential roles in multiple cellular processes, including osteogenic differentiation and bone healing. In this Review, we discuss the most recent advances in our understanding of the regulatory and non-coding RNA biology of osteogenic differentiation in stem, stromal and progenitor cells. We focused on circular RNAs, small nucleolar RNAs and PIWI-interacting RNAs and comprehensively summarized their biological functions as well as discussed their significance for bone healing and tissue regeneration.
Keywords: non-coding RNAs, regulatory RNAs, Osteogenic differentiation, bone fracture, bone healing, circular RNAs, small nucleolar RNAs, PIWI-interacting RNAs
Received: 20 Aug 2024; Accepted: 04 Dec 2024.
Copyright: © 2024 Aranguren, Cole, Dargan, Sarlo, Choi, Satapathy and Ferreira de Vasconcellos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jaira Ferreira de Vasconcellos, James Madison University, Harrisonburg, United States
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