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REVIEW article

Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1481505

An update on ox-LDL inducing vascular smooth muscle cell-derived foam cell in atherosclerosis

Provisionally accepted
Jingjing Guo Jingjing Guo Laijing Du Laijing Du *
  • The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China

The final, formatted version of the article will be published soon.

    Excess cholesterol accumulation induces accumulation of foam cells, eventually accelerating atherosclerosis progress. Historically, the mechanisms of macrophage-derived foam cells attracted extensive attention because of their central role in plaque development, which was challenged by lineage tracing in union with single-cell sequencing (sc-seq). Accumulated studies uncover how vascular smooth muscle cells (VSMCs) proliferate and migrate to the vascular intima and accumulate, then transform into foam cells induced by surplus lipid, at last, accounting for 30% to 70%, which become the main component of foam cells in atherosclerotic plaques of both mice and humans. Therefore, the mechanisms of VSMC-derived foam cells have been captured more attention. The review intends to summarize the mechanism of transformation of VSMCs into foam cells induced by oxidized low-density lipoproteins (ox-LDL) in atherosclerosis.

    Keywords: VSMCs, Foam cell, Atherosclerosis, ox-LDL, Cholesterol metabloism

    Received: 16 Aug 2024; Accepted: 08 Oct 2024.

    Copyright: © 2024 Guo and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Laijing Du, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.