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REVIEW article

Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1479720

The Oral Microbiota and Its Contribution to Carcinogenesis

Provisionally accepted
Xinlin Wang Xinlin Wang 1,2Xin He Xin He 3*Bin Zhong Bin Zhong 1*
  • 1 Department of Respiratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
  • 2 The First School of Clinical Medicine, Gannan Medical University, Ganzhou, Jiangxi Province, China
  • 3 Department of Respiratory Medicine;Jiangxi Provincial Branch of China Clinical Medical Research Center for Geriatric Diseases, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    The advancement of high-throughput sequencing technology in recent decades has led to a greater understanding of the components of the oral microbiota, providing a solid foundation for extensive research in this field. The oral microbiota plays an important role in an individual's overall health. It has been shown to be significantly correlated with chronic human diseases, including diabetes, rheumatoid arthritis, cardiovascular disease, periodontal disease, and Alzheimer's disease. Furthermore, tumor occurrence and development are closely related to the oral microbiome. Specific bacteria, such as Fusobacterium nucleatum(F. nucleatum), Porphyromonas gingivalis(P. gingivalis), Streptococcus, Streptomyces, Prevotella, and Fibrophagy gingivalis, play critical roles in cancer development. The oral microbiota has various oncogenic mechanisms, including bacterial inflammation, immunological suppression, tumor growth mediated by bacterial toxins, antiapoptotic activity, and carcinogenic effects.This paper reviews the role of the oral microbiota in the occurrence and progression of cancer and systematically elucidates the molecular mechanisms by which dysbiosis influences tumorigenesis and tumor progression. This information can provide a theoretical basis for exploring cancer treatment strategies and offer new insights for cancer prevention.

    Keywords: Oral microbiota, Fusobacterium nucleatum, Porphyromonas gingivalis, Cancer, oncogenic mechanisms

    Received: 12 Aug 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Wang, He and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xin He, Department of Respiratory Medicine;Jiangxi Provincial Branch of China Clinical Medical Research Center for Geriatric Diseases, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
    Bin Zhong, Department of Respiratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.