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REVIEW article

Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1472103
This article is part of the Research Topic Unraveling Human and Large Animal Stem Cells View all 4 articles

Stem cells and bio scaffolds for the treatment of cardiovascular diseases: New Insights

Provisionally accepted
Zahrasadat(Farnaz) Razavi Zahrasadat(Farnaz) Razavi 1Simin Farokhi Simin Farokhi 2Golnaz Mahmoudvand Golnaz Mahmoudvand 2Arian Karimi-Rouzbahani Arian Karimi-Rouzbahani 2Bahareh Farasati-Far Bahareh Farasati-Far 3Samaneh Tahmasebi-Ghorabi Samaneh Tahmasebi-Ghorabi 4Hamidreza Pazoki -Toroudi Hamidreza Pazoki -Toroudi 1Masoud Saadat-Fakhr Masoud Saadat-Fakhr 5Hamed Afkhami Hamed Afkhami 6,7,8*
  • 1 Physiology Research Center, Iran University of Medical Sciences, Tehran, Alborz, Iran
  • 2 Student Research Committee, USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran, Khorramabad, Lorestan, Iran
  • 3 Department of Chemistry, Iran University of Science and Technology, Tehran, Alborz, Iran
  • 4 Master of Health Education, Research Expert, Clinical Research Development Unit, Emam Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran, Ilam, Ilam, Iran
  • 5 Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  • 6 Cellular and Molecular Research Centre, Qom University of Medical Sciences, Qom, Iran, Qom, Iran
  • 7 Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Semnan, Iran
  • 8 Department of Medical Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran, Tehran, Alborz, Iran

The final, formatted version of the article will be published soon.

    Mortality and morbidity from cardiovascular diseases are common worldwide. In order to improve survival and quality of life for this patient population, extensive efforts are being made to establish effective therapeutic modalities. New treatment options are needed, it seems. In addition to treating cardiovascular diseases, cell therapy is one of the most promising medical platforms. One of the most effective therapeutic approaches in this area is stem cell therapy. In stem cell biology, multipotent stem cells and pluripotent stem cells are divided into two types. There is evidence that stem cell therapy could be used as a therapeutic approach for cardiovascular diseases based on multiple lines of evidence. The effectiveness of stem cell therapies in humans has been studied in several clinical trials. In spite of the challenges associated with stem cell therapy, it appears that resolving them may lead to stem cells being used in cardiovascular disease patients. This may be an effective therapeutic approach. By mounting these stem cells on biological scaffolds, their effect can be enhanced.

    Keywords: Cardiovascular Heart Disease, Heart Failure, stem cell, cell therapy, Bio Scaffold

    Received: 28 Jul 2024; Accepted: 01 Oct 2024.

    Copyright: © 2024 Razavi, Farokhi, Mahmoudvand, Karimi-Rouzbahani, Farasati-Far, Tahmasebi-Ghorabi, Pazoki -Toroudi, Saadat-Fakhr and Afkhami. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hamed Afkhami, Cellular and Molecular Research Centre, Qom University of Medical Sciences, Qom, Iran, Qom, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.