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REVIEW article

Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1463807

In Vitro Models of Leukemia Development: The Role of Very Small Leukemic Stem-Like Cells in the Cellular Transformation Cascade

Provisionally accepted
Jan Jakub Lica Jan Jakub Lica 1*Joanna Jakóbkiewicz-Banecka Joanna Jakóbkiewicz-Banecka 2*Andrzej Hellmann Andrzej Hellmann 3*
  • 1 Powiślańska College in Kwidzyn, Kwidzyn, Poland
  • 2 University of Gdansk, Gdansk, Pomeranian Voivodeship, Poland
  • 3 Medical University of Gdansk, Gdańsk, Pomeranian, Poland

The final, formatted version of the article will be published soon.

    Recent experimental findings indicate that cancer stem cells originate from transformed very small embryonic-like stem cells. This finding represents an essential advancement in uncovering the processes that drive the onset and progression of cancer. In continuously growing cell lines, for the first time, our team's follow-up research on leukemia, lung cancer, and healthy embryonic kidney cells revealed stages that resembles very small precursor stem cells. This review explores the origin of leukemic stem-like cells from very small leukemic stem-like cells establish from transformed very small embryonic-like stem cells. We explore theoretical model of acute myeloid leukemia initiation and progresses through various stages, as well basing the HL60 cell line, present its hierarchical stage development in vitro, highlighting the role of these very small precursor primitive stages. We also discuss the potential implications of further research into these unique cellular stages for advancing leukemia and cancer treatment and prevention.

    Keywords: very small progenitor and precursor stem cells, very small leukemic stem-like cells, acute myeloid leukemia development in vitro, Cellular transformations, HL60, A549

    Received: 15 Jul 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Lica, Jakóbkiewicz-Banecka and Hellmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jan Jakub Lica, Powiślańska College in Kwidzyn, Kwidzyn, Poland
    Joanna Jakóbkiewicz-Banecka, University of Gdansk, Gdansk, 80-952, Pomeranian Voivodeship, Poland
    Andrzej Hellmann, Medical University of Gdansk, Gdańsk, Pomeranian, Poland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.