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REVIEW article

Front. Cell Dev. Biol.
Sec. Cell Death and Survival
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1462339
This article is part of the Research Topic 10 years of Frontiers in Cell and Developmental Biology: Past Discoveries, Current Challenges and Future Perspectives View all 5 articles

Targeting Regulated Cell Death Pathways in Cancers for Effective Treatment: A Comprehensive Review

Provisionally accepted
Ruchi Saxena Ruchi Saxena 1*Craig M. Walsh Craig M. Walsh 2You-Wen He You-Wen He 1*
  • 1 Department of Integrative Immunobiology, School of Medicine, Duke University, Durham, United States
  • 2 Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, United States

The final, formatted version of the article will be published soon.

    Cancer is a complex disease characterized by specific "mission-critical" events that drive the uncontrolled growth and spread of tumor cells and their offspring. These events are essential for the advancement of the disease. One of the main contributors to these events is dysregulation of cell death pathwayssuch as apoptosis, necroptosis, ferroptosis, autophagy, pyroptosis, cuproptosis, parthanatos and-allows cancer cells to avoid programmed cell death and continue proliferating unabated. The different cell death pathways in cancers provide useful targets for cancer treatment. This review examines recent progresses in the preclinical and clinical development of targeting dysregulated cell death pathways for cancer treatment. To develop effective cancer therapies, it is essential to identify and target these mission-critical events that prevent tumor cells from timely death. By precisely targeting these crucial events, researchers can develop therapies with maximum impact and minimal side effects. A comprehensive understanding of the molecular and cellular mechanisms underlying these regulated cell death pathways will further the development of highly effective and personalized cancer treatments.

    Keywords: Regulated cell death pathway, cancer therapy, Apoptosis, Autophagy, necroptosis, ferroptosis, pyroptosis, cuproptosis

    Received: 11 Jul 2024; Accepted: 05 Nov 2024.

    Copyright: © 2024 Saxena, Walsh and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ruchi Saxena, Department of Integrative Immunobiology, School of Medicine, Duke University, Durham, United States
    You-Wen He, Department of Integrative Immunobiology, School of Medicine, Duke University, Durham, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.