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REVIEW article

Front. Cell Dev. Biol.
Sec. Signaling
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1461278
This article is part of the Research Topic Unraveling the Role of Receptor Signaling in Tumorigenesis and Cancer Therapy View all articles

Unraveling the Interplay: Exploring Signaling Pathways in Pancreatic Cancer in the Context of Pancreatic Embryogenesis

Provisionally accepted
Sashikanta Swain Sashikanta Swain Ravi K. Narayan Ravi K. Narayan Pravash R. Mishra Pravash R. Mishra *
  • All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

The final, formatted version of the article will be published soon.

    Pancreatic cancer continues to be a deadly disease because of its delayed diagnosis and aggressive tumor biology. Oncogenes and risk factors are being reported to influence the signaling pathways involved in pancreatic embryogenesis leading to pancreatic cancer genesis. Although studies using rodent models have yielded insightful information, the scarcity of human pancreatic tissue has made it difficult to comprehend how the human pancreas develops. Transcription factors like IPF1/PDX1, HLXB9, PBX1, MEIS, Islet-1, and signaling pathways, including Hedgehog, TGF-β, and Notch, are directing pancreatic organogenesis. Any derangements in the above pathways may lead to pancreatic cancer.TP53 and CDKN2A are tumor suppressor genes, and the mutations in TP53 and somatic loss of CDKN2A are the drivers of pancreatic cancer. This review clarifies the complex signaling mechanism involved in pancreatic cancer, the same signaling pathways in pancreas development, the current therapeutic approach targeting signaling molecules, and the mechanism of action of risk factors in promoting pancreatic cancer.

    Keywords: Pancreatic Cancer, transcription factor, signaling pathway, Therapeutic approach, Embryogenesis

    Received: 08 Jul 2024; Accepted: 13 Aug 2024.

    Copyright: © 2024 Swain, Narayan and Mishra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Pravash R. Mishra, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.