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ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Molecular and Cellular Reproduction
Volume 12 - 2024 |
doi: 10.3389/fcell.2024.1461132
This article is part of the Research Topic Genotoxic Pathways of Reproductive Outcomes View all articles
Obesity May Impair Response to Ovarian Stimulation. A Retrospective Observational Study on Oocyte Quality
Provisionally accepted
Irene Iavarone
*
Daniela Mele
Francesca Caprio
Giada Andreoli
Maria Giovanna Vastarella
Pasquale De Franciscis
Carlo Ronsini
*- Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy
Background: Ovulatory dysfunction is more common in women with obesity. Body fat distribution is also crucial because anovulatory women have a greater waist circumference and more abdominal fat than ovulatory women of similar BMI. The primary aim of the present study is to determine whether there is a relationship between BMI and reproductive characteristics, including hormonal values, antral follicle count (AFC), endometrial assessment at transvaginal ultrasound evaluation (TVUS) during controlled ovarian stimulation (COS), and oocyte retrieval after Ovum Pick-Up (OPU). Methods: Data from a cohort of 183 patients were analyzed and divided into three groups based on weight status: normal weight, overweight, and obesity. Evaluated reproductive characteristics included: age, basal values of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17-beta-estradiol (E2), thyroid stimulating hormone (TSH), anti-müllerian hormone (AMH), antral-follicle-count (AFC), duration of COS, E2, and progesterone at the last monitoring, TVUS endometrial thickness at the last monitoring before OPU, FOI after OPU. Additionally, the number of meiosis II oocytes retrieved (MII), the total dose of FSH administered, the ratio between MII and total FSH administered, and OSI were registered. Results: AMH levels were significantly lower in obese patients compared to normal weight and overweight women (1. 05 IQR 1.20, 1.58 IQR 2.16, 1.32 IQR 1.38, respectively,. When looking at the MII/FSH ratio, the normal weight group showed a median value of 3.3 with an IQR of 4.0, the overweight group showed a median value of 2.3 with an IQR of 1.9, and the obese group had a median value of 2.6 with an IQR of 2.8. Those data were statistically significant (p-value = 0.049). Conclusions: These results emphasize the importance of considering weight status in fertility assessment and treatment planning.
Keywords: Body Mass Index, Antral follicle count, mature oocytes, Obesity, ovarian reserve
Received: 07 Jul 2024; Accepted: 23 Sep 2024.
Copyright: © 2024 Iavarone, Mele, Caprio, Andreoli, Vastarella, De Franciscis and Ronsini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Irene Iavarone, Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy
Carlo Ronsini, Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy
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