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REVIEW article

Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1459246
This article is part of the Research Topic Current Methods for Detecting and Diagnosing Stem Cell Pathogenesis: A Focus on Translational Interventions in the Contemporary Disease and Technology Landscape View all 5 articles

Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review

Provisionally accepted
Lebin Ke Lebin Ke 1Yingying Cao Yingying Cao 2Zhiwei Lu Zhiwei Lu 3Jamal Halajzadeh Jamal Halajzadeh 4*
  • 1 Wenzhou Medical University, Wenzhou, Zhejiang Province, China
  • 2 Tiantai People's Hospital of Zhejiang Province, Taizhou, Zhejiang Province, China
  • 3 Hangzhou Wuyunshan Hospital, Hangzhou, Jiangsu Province, China
  • 4 Maragheh University of Medical Sciences, Maragheh, Iran

The final, formatted version of the article will be published soon.

    Neurological disorders are being increasingly recognized as major causes of death and disability around the world. Neurological disorders refer to a broad range of medical conditions that affect the brain and spinal cord. These disorders can have various causes, including genetic factors, infections, trauma, autoimmune reactions, or neurodegenerative processes. Each disorder has its own unique symptoms, progression, and treatment options. Optimal communication between interneurons and neuron-glia cells within the homeostatic microenvironment is of paramount importance. Within this microenvironment, exosomes play a significant role in promoting intercellular communication by transferring a diverse cargo of contents, including proteins, lipids, and non-coding RNAs (ncRNAs). Partially, nervous system homeostasis is preserved by various stem cell-derived exosomal ncRNAs, which include circular RNAs (circRNAs), long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and PIWI-interacting RNAs (piRNAs) (1). The diversity of these exosomal ncRNAs suggests their potential to influence multiple pathways and cellular processes within the nervous system.Stem cell-derived exosomes and their ncRNA contents have been investigated for potential therapeutic uses in neurological disorders, owing to their demonstrated capabilities in neuroprotection, neuroregeneration, and modulation of disease-related pathways. The ability of stem cell-derived exosomes to cross the blood-brain barrier makes them a promising delivery vehicle for therapeutic ncRNAs. This review aims to summarize the current understanding of different stem cell-derived exosomal ncRNAs and their therapeutic potential and clinical applications.

    Keywords: Stem cell-derived exosome, ncRNAs, Neurological Diseases, Treatment, Exosomes

    Received: 03 Jul 2024; Accepted: 26 Sep 2024.

    Copyright: © 2024 Ke, Cao, Lu and Halajzadeh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jamal Halajzadeh, Maragheh University of Medical Sciences, Maragheh, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.