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REVIEW article
Front. Cell Dev. Biol.
Sec. Signaling
Volume 12 - 2024 |
doi: 10.3389/fcell.2024.1459183
This article is part of the Research Topic Revolutionizing Cancer Treatment: Navigating the Intricate Landscape of Cellular Signaling Networks View all 7 articles
Copper homeostasis and cuproptosis in gynecological cancers
Provisionally accepted- 1 Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China
- 2 Longquan People's Hospital, Lishui, China
Copper (Cu) is an essential trace element involved in a variety of biological processes, such as antioxidant defense, mitochondrial respiration, and bio-compound synthesis. In recent years, a novel theory called cuproptosis has emerged to explain how Cu induces programmed cell death. Cu targets lipoylated enzymes in the tricarboxylic acid cycle and subsequently triggers the oligomerization of lipoylated dihydrolipoamide S-acetyltransferase, leading to the loss of Fe-S clusters and induction of heat shock protein 70. Gynecological malignancies including cervical cancer, ovarian cancer and uterine corpus endometrial carcinoma significantly impact women's quality of life and even pose a threat to their lives. Excessive Cu can promote cancer progression by enhancing tumor growth, proliferation, angiogenesis and metastasis through multiple signaling pathways. However, there are few studies investigating gynecological cancers in relation to cuproptosis. Therefore, this review discusses Cu homeostasis and cuproptosis while exploring the potential use of cuproptosis for prognosis prediction as well as its implications in the progression and treatment of gynecological cancers. Additionally, we explore the application of Cu ionophore therapy in treating gynecological malignancies.
Keywords: copper homeostasis, cuproptosis, gynecological cancers, Prognosis prediction, Functional Analysis, Copper ionophore
Received: 03 Jul 2024; Accepted: 06 Sep 2024.
Copyright: © 2024 Huang, Lian and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Changzhong Li, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China
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