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REVIEW article

Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1457319
This article is part of the Research Topic Epigenetic Regulation of Kidney Development and Disease View all 7 articles

Noncoding RNA, friend or foe for nephrolithiasis?

Provisionally accepted
Qing  Wang Qing Wang 1*Zhen Lu  Yang Zhen Lu Yang 1Xiaolong  Chen Xiaolong Chen 1Yuanyuan  Yang Yuanyuan Yang 2*Kehua  Jiang Kehua Jiang 1*
  • 1 Guizhou Provincial People's Hospital, Guiyang, China
  • 2 Huazhong University of Science and Technology, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    Nephrolithiasis is one of the most common diseases in urology, characterized by notable incidence and recurrence rates, leading to significant morbidity and financial burden. Despite its prevalence, the precise mechanisms underlying stone formation remain incompletely understood, thus hindering significant advancements in kidney stone management over the past three decades. Investigating the pivotal biological molecules that govern stone formation has consistently been a challenging and highpriority task. A significant portion of mammalian genomes are transcribed into noncoding RNAs (ncRNAs), which have the ability to modulate gene expression and disease progression. They are thus emerging as a novel target class for diagnostics and pharmaceutical exploration. In recent years, the role of ncRNAs in stone formation has attracted burgeoning attention. They have been found to influence stone formation by regulating ion transportation, oxidative stress injury, inflammation, osteoblastic transformation, autophagy, and pyroptosis. These findings contributes new perspectives on the pathogenesis of nephrolithiasis. To enhance our understanding of the diagnostic and therapeutic potential of nephrolithiasis-associated ncRNAs, we summarized the expression profiles, biological functions, and clinical significance of these ncRNAs in the current review.

    Keywords: ncRNAs, Nephrolithiasis, Calcium Oxalate, biomarkers, therapeutic targets

    Received: 01 Jul 2024; Accepted: 08 Nov 2024.

    Copyright: © 2024 Wang, Yang, Chen, Yang and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qing Wang, Guizhou Provincial People's Hospital, Guiyang, China
    Yuanyuan Yang, Huazhong University of Science and Technology, Wuhan, 430074, Hubei Province, China
    Kehua Jiang, Guizhou Provincial People's Hospital, Guiyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.