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ORIGINAL RESEARCH article

Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1454084
This article is part of the Research Topic New Insights on Bone, Cartilage and Degenerative Skeletal Diseases: From Molecular Mechanism to Clinical Therapy View all 3 articles

Plasma metabolites associated with biopsychosocial parameters in overweight/obese women with severe knee osteoarthritis

Provisionally accepted

The final, formatted version of the article will be published soon.

    Obesity aligned with quadriceps muscle weakness contributes to the high incidence of knee osteoarthritis (KOA), which is prevalent in women. Although molecular signatures of KOA have been suggested, the association between biopsychosocial responses and the plasma metabolomic profile in overweight/obese women with KOA remains in its early stages of investigation. This study aims to associate the plasma metabolome with biopsychosocial parameters of overweight/obese women diagnosed with KOA. Twenty-eight overweight/obese women (Control-n=14; KOA-n=14) underwent two visits to the laboratory. Functional tests and questionnaires assessing biopsychosocial parameters were administered during the first visit. After 48 hours, the participants returned to the laboratory for blood collection. Specific to the KOA condition, the Numerical Pain Rating Scale (NPRS), Tampa Scale for Kinesiophobia (TSK), and Knee injury and Osteoarthritis Outcome Score (KOOS) were applied. Thirteen molecules were different between groups, and four correlated with KOA's biopsychosocial parameters. DG 22:4-2OH and gamma-Glutamylvaline were inversely associated with KOSS leisure and TSK score, respectively. LysoPE 18:0 and LysoPE 20:5 were positively associated with KOSS symptoms and TSK score, respectively. While the correlations of LysoPE 18:0 and gamma-Glutamylvaline are supported by existing literature, this is not the case for DG 22:4-2OH and LysoPE 20:5. Further studies are recommended to better elucidate these correlations before dismissing their potential involvement in the biopsychosocial factors of the disease.

    Keywords: Osteoarthritis, Metabolomics, biopsychosocial parameters, Knee, woman

    Received: 24 Jun 2024; Accepted: 23 Aug 2024.

    Copyright: © 2024 Lisboa, Benevento, Kaneko, Bertolucci, Rosini, Sardim, Ruiz, dos Reis, Porcari and Messias. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Leonardo H. Messias, Sao Francisco University, Braganca Paulista, Brazil

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