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MINI REVIEW article

Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1446050

Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes

Provisionally accepted
Haitao Zhuo Haitao Zhuo 1*Yunfei Chen Yunfei Chen 2Guifang Zhao Guifang Zhao 2,3
  • 1 Guangzhou Medical University, Guangzhou, China
  • 2 Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States
  • 3 Department of Pathology, Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Mesenchymal stem cells (MSCs) primarily secrete physiologically functional exosomes via paracrine effects that act on various adjacent and distant cells, thus exerting their therapeutic effects. In recent years, hypoxic preconditioning, as a novel MSC culture mode, has emerged as a research hotspot. Many previous studies have shown the role and underlying regulatory mechanisms of hypoxic preconditioning in various diseases, which has provided sufficient reference materials for the MSC research field. Therefore, this review summarizes the progress in application of hypoxia-preconditioned MSC-derived exosomes that substantially increases and improves the biological activity of specific molecules, such as microRNA.

    Keywords: hypoxic preconditioning, Mesenchymal Stem Cells, Exosomes, microRNA, molecular mechanism

    Received: 12 Jun 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Zhuo, Chen and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Haitao Zhuo, Guangzhou Medical University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.