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REVIEW article

Front. Cell Dev. Biol.
Sec. Cell Adhesion and Migration
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1434378

Integrins in Cancer Stem Cells

Provisionally accepted
Siqi Gou Siqi Gou 1ANQI WU ANQI WU 2Zhigang Luo Zhigang Luo 1*
  • 1 Department of urology, Hengyang Medical School, Second Affiliated Hospital of University of South China, Hengyang, China
  • 2 Hengyang Medical School, Second Affiliated Hospital of University of South China, Hengyang, China

The final, formatted version of the article will be published soon.

    Integrins are a class of adhesion receptors on cell membranes, consisting of α and β subunits. By binding to the extracellular matrix, integrins activate intracellular signaling pathways, participating in every step of cancer initiation and progression.Tumor stem cells possess self-renewal and self-differentiation abilities, along with strong tumorigenic potential. In this review, we discussed the role of integrins in cancer, with a focus on their impact on tumor stem cells and tumor stemness. This will aid in targeting tumor stem cells as a therapeutic approach, leading to the exploration of novel cancer treatment strategies. 制表位: 不在 19.78 字符 设置格式[szeki kuo]: : as a stemness markers and regulation of tumor stemness 删除[szeki kuo [2]]:

    Keywords: integrin, Cancer, stem cell, Stemness, Stemness marker

    Received: 20 May 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Gou, WU and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhigang Luo, Department of urology, Hengyang Medical School, Second Affiliated Hospital of University of South China, Hengyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.