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REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Adhesion and Migration
Volume 12 - 2024 |
doi: 10.3389/fcell.2024.1434378
Integrins in Cancer Stem Cells
Provisionally accepted- 1 Department of urology, Hengyang Medical School, Second Affiliated Hospital of University of South China, Hengyang, China
- 2 Hengyang Medical School, Second Affiliated Hospital of University of South China, Hengyang, China
Integrins are a class of adhesion receptors on cell membranes, consisting of α and β subunits. By binding to the extracellular matrix, integrins activate intracellular signaling pathways, participating in every step of cancer initiation and progression.Tumor stem cells possess self-renewal and self-differentiation abilities, along with strong tumorigenic potential. In this review, we discussed the role of integrins in cancer, with a focus on their impact on tumor stem cells and tumor stemness. This will aid in targeting tumor stem cells as a therapeutic approach, leading to the exploration of novel cancer treatment strategies. 制表位: 不在 19.78 字符 设置格式[szeki kuo]: : as a stemness markers and regulation of tumor stemness 删除[szeki kuo [2]]:
Keywords: integrin, Cancer, stem cell, Stemness, Stemness marker
Received: 20 May 2024; Accepted: 12 Aug 2024.
Copyright: © 2024 Gou, WU and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhigang Luo, Department of urology, Hengyang Medical School, Second Affiliated Hospital of University of South China, Hengyang, China
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