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REVIEW article

Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1430486
This article is part of the Research Topic Cancer Pathogenesis: Molecular and Cellular Mechanisms of Tumor evolution, Therapy-Resistance and Immune Evasion View all 5 articles

New insight into the CNC-bZIP member, NFE2L3, in human diseases

Provisionally accepted
Guanghui Xiong Guanghui Xiong 1*Jie Li Jie Li 2*Fuli Yao Fuli Yao 1*Fang Yang Fang Yang 3,4*Yuancai Xiang Yuancai Xiang 1*
  • 1 Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southwest Medical University, China, Sichuan, China
  • 2 Department of Anaesthesia, The Affiliated Hospital, Southwest Medical University,, Luzhou, Sichuan 646000, China
  • 3 Department of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan Province, China
  • 4 Department of Pathophysiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Nuclear factor erythroid 2 (NF-E2)-related factor 3 (NFE2L3), a member of the CNC-bZIP subfamily and widely found in a variety of tissues, is an endoplasmic reticulum (ER) membraneanchored transcription factor that can be released from the ER and moved into the nucleus to bind the promoter region to regulate a series of target genes involved in antioxidant, inflammatory responses, and cell cycle regulation in response to extracellular or intracellular stress. Recent research, particularly in the past five years, has shed light on NFE2L3's participation in diverse biological processes, including cell differentiation, inflammatory responses, lipid homeostasis, immune responses, and tumor growth. Notably, NFE2L3 has been identified as a key player in the development and prognosis of multiple cancers including colorectal cancer, thyroid cancer, breast cancer, hepatocellular carcinoma, gastric cancer, renal cancer, bladder cancer, esophageal squamous cell carcinoma, T cell lymphoblastic lymphoma, pancreatic cancer, and squamous cell carcinoma. Furthermore, research has linked NFE2L3 to other cancers such as lung adenocarcinoma, malignant pleural mesothelioma, ovarian cancer, glioblastoma multiforme, and laryngeal carcinoma, indicating its potential as a target for innovative cancer treatment approaches. Therefore, to gain a better understanding of the role of NFE2L3 in disease, this review offers insights into the discovery, structure, function, and recent advancements in the study of NFE2L3 to lay the groundwork for the development of NFE2L3-targeted cancer therapies.

    Keywords: Cancer, Homoeostasis, stress, CNC-bZIP, Nfe2l3/Nrf3, post-transcriptional modification, Transcriptional regulation

    Received: 10 May 2024; Accepted: 08 Jul 2024.

    Copyright: © 2024 Xiong, Li, Yao, Yang and Xiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Guanghui Xiong, Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southwest Medical University, China, Sichuan, China
    Jie Li, Department of Anaesthesia, The Affiliated Hospital, Southwest Medical University,, Luzhou, Sichuan 646000, China
    Fuli Yao, Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southwest Medical University, China, Sichuan, China
    Fang Yang, Department of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan Province, China
    Yuancai Xiang, Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southwest Medical University, China, Sichuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.