Skip to main content

REVIEW article

Front. Cell Dev. Biol.
Sec. Epigenomics and Epigenetics
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1426508

Histone deacetylases: potential therapeutic targets for idiopathic pulmonary fibrosis

Provisionally accepted
Hai-peng Cheng Hai-peng Cheng *Shi-He Jiang Shi-He Jiang Jin Cai Jin Cai Zi-qiang Luo Zi-qiang Luo Xiao-Hong Li Xiao-Hong Li *DanDan FENG DanDan FENG *
  • Central South University, Changsha, China

The final, formatted version of the article will be published soon.

    Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown origin and the most common interstitial lung disease. However, therapeutic options for IPF are limited, and novel therapies are urgently needed. Histone deacetylases (HDACs) are enzymes that participate in balancing histone acetylation activity for chromatin remodeling and gene transcription regulation. Increasing evidence suggests that the HDAC family is linked to the development and progression of chronic fibrotic diseases, including IPF. This review aims to summarize available information on HDACs and related inhibitors and their potential applications in treating IPF. In the future, HDACs may serve as novel targets, which can aid in understanding the etiology of PF, and selective inhibition of single HDACs or disruption of HDAC genes may serve as a strategy for treating PF.

    Keywords: Histone deacetylase, Idiopathic Pulmonary Fibrosis, histone acetylation, Fibroblasts, HDAC inhibitors

    Received: 01 May 2024; Accepted: 03 Jul 2024.

    Copyright: © 2024 Cheng, Jiang, Cai, Luo, Li and FENG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hai-peng Cheng, Central South University, Changsha, China
    Xiao-Hong Li, Central South University, Changsha, China
    DanDan FENG, Central South University, Changsha, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.