Chuanchao Su ^* Yiwen Xue SIYU FAN Xin Sun Qian Si Zhen Gu Jingfei Wang Runzhi Deng ^*

• Nanjing University, Nanjing, China

Marked by iron buildup and lipid peroxidation, ferroptosis is a relatively new regulatory cell death(RCD) pathway. Many diseases like cancer, myocardial ischemia-reperfusion injury(MIRI), neurological disorders and acute renal failure(AKI) are corelated with ferroptosis. The main molecular processes of ferroptosis discovered yet will be presented here, along with the approaches in which it interacts with tumour-associated signaling pathways and its uses in systemic therapy, radiation therapy, and immunotherapy managing tumors. 1 Introduction A strong correlation exists between regulatory cell death (RCD) and the onset, advancement, and management of cancer. RCD is critical for immune response, homeostasis maintenance, embryogenesis and other processes[Allocati N et al,2015]. Distinct from accidental cell death, it's regulated by a variety of signal transduction pathways and is susceptible to genetic and pharmacological interferences, which is [Galluzzi L et al,2018]. Several RCD types, each with their distinct molecular mechanisms, have been found by researchers, including apoptosis, necrotizing apoptosis, pyroptosis, parthanatos and ferroptosis[Tang D et al,2019](Figure 1). The two most common methods for inducing apoptosis are death receptors and mitochondrial pathways. Induced by activation of caspase9[Fuchs Y et al,2011] and regulated by Bcl-XL, Bcl-2, Bak, Bax and p53, apoptosis is a process that involves phosphatidylserine shift, volumn reduction, chromatin agglutination and nuclear division. Furthermore, mitochondria will degrade to maintain cellular homeostasis, and excessive ROS will induce autophagy during apoptosis[Guo QQ et al,2020]. Involving activating receptor-interacting protein kinase 1 or 3(RIP1 or RIP3) and pseudokinase MLKL, necroptotic apoptosis accumulates of ATP, ROS and calcium, changes mitochondria permeability, creats pore, increases cell and organelle volume, ruptures plasma membrane and gets cell content leaked[Vanden Berghe T et al,2014; Yuan J et al,2010; Vandenabeele P et al,2010]. In pyroptosis, cells undergo expansion and formation of protrusions. This comes with nuclear contraction and DNA breakage[Bergsbaken T et al,2009]. Its mechanisms of action involves gasdermin cleavage, which releases the N-terminal domain and subequently oligomerizes and