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REVIEW article

Front. Cell Dev. Biol.
Sec. Signaling
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1423665

The JNK signaling pathway in intervertebral disc degeneration

Provisionally accepted
Liu Ganggang Liu Ganggang 1gao lu gao lu 1*yuncai wang yuncai wang 1*Xin-Sheng Xie Xin-Sheng Xie 1xuejiao gao xuejiao gao 2*xingjie wu xingjie wu 1*
  • 1 Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China
  • 2 the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China

The final, formatted version of the article will be published soon.

    Intervertebral disc degeneration (IDD) serves as the underlying pathology for various spinal degenerative conditions and is a primary contributor to low back pain (LBP). Recent studies have revealed a strong correlation between IDD and biological processes such as Programmed Cell Death (PCD), cellular senescence, inflammation, cell proliferation, extracellular matrix (ECM) degradation, and oxidative stress (OS). Of particular interest is the emerging evidence highlighting the significant involvement of the JNK signaling pathway in these fundamental biological processes of IDD. This paper explores the potential mechanisms through the JNK signaling pathway influences IDD in diverse ways. The objective of this article is to offer a fresh perspective and methodology for indepth investigation into the pathogenesis of IDD by thoroughly examining the interplay between the JNK signaling pathway and IDD. Moreover, this paper summarizes the drugs and natural compounds that alleviate the progression of IDD by regulating the JNK signaling pathway. This paper aims to identify potential therapeutic targets and strategies for IDD treatment, providing valuable insights for clinical application.

    Keywords: Intervertebral disc degeneration (IDD), JNK path, programmed cell death (PCD), Cellular senescence (CS), Cell Proliferation，inflammation, extracellar matrix (ECM) degradation, Oxidative stress (OS)

    Received: 26 Apr 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Ganggang, lu, wang, Xie, gao and wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    gao lu, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China
    yuncai wang, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China
    xuejiao gao, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China
    xingjie wu, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.