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REVIEW article
Front. Cell Dev. Biol.
Sec. Signaling
Volume 12 - 2024 |
doi: 10.3389/fcell.2024.1423665
The JNK signaling pathway in intervertebral disc degeneration
Provisionally accepted- 1 Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China
- 2 the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China
Intervertebral disc degeneration (IDD) serves as the underlying pathology for various spinal degenerative conditions and is a primary contributor to low back pain (LBP). Recent studies have revealed a strong correlation between IDD and biological processes such as Programmed Cell Death (PCD), cellular senescence, inflammation, cell proliferation, extracellular matrix (ECM) degradation, and oxidative stress (OS). Of particular interest is the emerging evidence highlighting the significant involvement of the JNK signaling pathway in these fundamental biological processes of IDD. This paper explores the potential mechanisms through the JNK signaling pathway influences IDD in diverse ways. The objective of this article is to offer a fresh perspective and methodology for indepth investigation into the pathogenesis of IDD by thoroughly examining the interplay between the JNK signaling pathway and IDD. Moreover, this paper summarizes the drugs and natural compounds that alleviate the progression of IDD by regulating the JNK signaling pathway. This paper aims to identify potential therapeutic targets and strategies for IDD treatment, providing valuable insights for clinical application.
Keywords: Intervertebral disc degeneration (IDD), JNK path, programmed cell death (PCD), Cellular senescence (CS), Cell Proliferation,inflammation, extracellar matrix (ECM) degradation, Oxidative stress (OS)
Received: 26 Apr 2024; Accepted: 09 Sep 2024.
Copyright: © 2024 Ganggang, lu, wang, Xie, gao and wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
gao lu, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China
yuncai wang, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China
xuejiao gao, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China
xingjie wu, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China
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