This article is a correction to:
Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome
Chunzhu Song1
Kendal Broadie1,2,3,4*- 1Department of Biological Sciences, College of Arts and Science, Vanderbilt University, Nashville, TN, United States
- 2Department of Cell and Developmental Biology, School of Medicine, Vanderbilt University, Nashville, TN, United States
- 3Kennedy Center for Research on Human Development, Nashville, TN, United States
- 4Vanderbilt Brain Institute, School of Medicine, Vanderbilt University and Medical Center, Nashville, TN, United States
A Corrigendum on
Dysregulation of BMP, Wnt, and insulin signaling in fragile X syndrome
by Song C and Broadie K (2022). Front. Cell Dev. Biol. 10:934662. doi: 10.3389/fcell.2022.934662
In the published article, there was an error in the legend of Figure 2 as published. The expression level of glial Draper with loss of neuronal FMRP was mistakenly summarized. Based on the conclusion of our reviewed paper, loss of neuronal FMRP should decrease the expression level of glial Draper. The corrected Figure 2 legend appears below:
Figure 2 | Secreted signals regulated by neuronal FMRP orchestrate glial phagocytosis. In early adult Drosophila brain PDF-Tri neurons, FMRP is proposed to promote the secretion of insulin-like peptides (ILPs) that drive glial insulin receptor phosphorylation (InR-P) to trigger glial phagocytosis of neuronal processes. In the glia, Draper (Drpr) phagocytosis receptor expression is decreased by loss of neuronal FMRP. However, the neuronal Drpr ligands (for example, Pretaporter, phosphatidylserine) involved in this FMRP-dependent mechanism remain unknown. Neuronal FMRP may regulate numerous other “find me” and “eat me” secreted neural signals that recruit glia and instruct glial phagocytosis, ranging from individual synapses to whole brain neurons.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: bone morphogenetic protein, insulin-like peptide, fragile x mental retardation protein, wingless, Drosophila
Citation: Song C and Broadie K (2024) Corrigendum: Dysregulation of BMP, Wnt, and insulin signaling in fragile X syndrome. Front. Cell Dev. Biol. 12:1416720. doi: 10.3389/fcell.2024.1416720
Received: 13 April 2024; Accepted: 14 May 2024;
Published: 04 June 2024.
Edited and reviewed by:
Brian Storrie, University of Arkansas for Medical Sciences, United StatesCopyright © 2024 Song and Broadie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Kendal Broadie, kendal.broadie@vanderbilt.edu