Skip to main content

ORIGINAL RESEARCH article

Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1412363

Research Hotspots and Trends of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Drug Delivery: A Bibliometric and Visualization Analysis from 2013 to 2023

Provisionally accepted
Tianyuan Zhao Tianyuan Zhao 1Yuhao Mu Yuhao Mu 2Kaini Liang Kaini Liang 3Fanfan Zhou Fanfan Zhou 4Qiyuan Lin Qiyuan Lin 5Fuyang Cao Fuyang Cao 6Feifei Zhou Feifei Zhou 1Zhen Yang Zhen Yang 4*
  • 1 Peking University Third Hospital, Haidian, Beijing Municipality, China
  • 2 School of Medicine, Nankai University, Tianjin, China
  • 3 Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, Beijing Municipality, China
  • 4 Arthritis Clinical and Research Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, China
  • 5 Peking University People's Hospital, Beijing, Beijing Municipality, China
  • 6 Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China

The final, formatted version of the article will be published soon.

    Our study reveals a comprehensive landscape of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in drug delivery, with a focus between the period of 2013 to 2023. Leveraging Web of Science (WoS) and VOSviewer for data collection in-depth bibliometric analysis respectively, we meticulously done a bibliographic analysis encompassed bibliographic coupling, co-citation, coauthorship, and co-occurrence trends. The results unveiled a total of 1045 publications, highlighting a steady rise in global research interest and publication rates. China dominated in terms of publication count, H-index, prolific authors, and funding, while the United States of America (USA) showcased its research prowess with the highest total citations, as well as strong average citation and H-index rankings. The journal Pharmaceutics led in publication volume, followed by the Journal of Controlled Release with the most robust total link strength. Leading institutions like Shanghai Jiao Tong University, Zhejiang University, and Harvard University were at the vanguard of this research.VOSviewer analysis identified four primary research clusters, which are tissue engineering, cancer, neurological diseases, and targeted delivery, while Citespace clustering further distilled this into ten key thematic areas, including differentiation, tissue regeneration, drug resistance and etc. This pioneering visualization and bibliometric assessment not only offer a holistic overview of the developmental trends and intellectual structure in the field of MSC-EVs for drug delivery over the last decade but also accentuates the increasing global importance of this field, particularly highlighting the pivotal roles of China and the USA. These insights lay a foundation for guiding future research trajectories and spotlighting the nascent frontiers in MSC-EV-based drug delivery..

    Keywords: research hotspots and trends, mesenchymal stem cell, extracellular vesicles, Bibliometric, visualization

    Received: 04 Apr 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Zhao, Mu, Liang, Zhou, Lin, Cao, Zhou and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhen Yang, Arthritis Clinical and Research Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.