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REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 12 - 2024 |
doi: 10.3389/fcell.2024.1397945
This article is part of the Research Topic Cancer Pathogenesis: Molecular and Cellular Mechanisms of Tumor evolution, Therapy-Resistance and Immune Evasion View all 8 articles
Understanding the Role of miRNAs in Cervical Cancer Pathogenesis and Therapeutic Responses
Provisionally accepted
Prashant Chauhan
1
Deena Elsori
2*
Sorabh Lakhanpal
3*
Rahul Kumar
4*
Mohammed Alsaweed
5
Danish Iqbal
6
Pratibha Pandey
7
Ayoub Al Othaim
5*
Dr. Fahad Khan
8*- 1 MPA Research, Greater Noida, India
- 2 Rabdan Academy, Abu Dhabi, United Arab Emirates
- 3 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
- 4 Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, Baddi, India
- 5 Majmaah University, Al Majma'ah, Riyadh, Saudi Arabia
- 6 Buraydah Colleges, Buraidah, Saudi Arabia
- 7 Center for Research Impact and Outcome, Chitkara University, Chandigarh, India
- 8 Saveetha Medical College & Hospital, Chennai, Tamil Nadu, India
Cervical cancer (CC) is the most common cancer in women and poses a serious threat to health.Despite familiarity with the factors affecting its etiology, initiation, progression, treatment strategies, and even resistance to therapy, it is considered a significant problem for women.However, several factors have greatly affected the previous aspects of CC progression and treatment in recent decades. miRNAs are short non-coding RNA sequences that regulate gene expression by inhibiting translation of the target mRNA. miRNAs play a crucial role in CC pathogenesis by promoting cancer stem cell (CSC) proliferation, postponing apoptosis, continuing the cell cycle, and promoting invasion, angiogenesis, and metastasis. Similarly, miRNAs influence important CC-related molecular pathways, such as the PI3K/AKT/mTOR signaling pathway, Wnt/β-catenin system, JAK/STAT signaling pathway, and MAPK signaling pathway. Moreover, miRNAs affect the response of CC patients to chemotherapy and radiotherapy. Consequently, this review aims to provide an acquainted summary of onco miRNAs and tumor suppressor (TS) miRNAs and their potential role in CC pathogenesis and therapy responses by focusing on the molecular pathways that drive them.
Keywords: tumour suppressor, miRNAs, cervical cancer, Oncogenic mirnas, Signalling pathway
Received: 08 Mar 2024; Accepted: 08 Aug 2024.
Copyright: © 2024 Chauhan, Elsori, Lakhanpal, Kumar, Alsaweed, Iqbal, Pandey, Al Othaim and Khan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Deena Elsori, Rabdan Academy, Abu Dhabi, United Arab Emirates
Sorabh Lakhanpal, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India
Rahul Kumar, Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, Baddi, India
Ayoub Al Othaim, Majmaah University, Al Majma'ah, 15341, Riyadh, Saudi Arabia
Dr. Fahad Khan, Saveetha Medical College & Hospital, Chennai, Tamil Nadu, India
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