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REVIEW article

Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1396836
This article is part of the Research Topic Perspectives on Omics Analysis in Solid Tumors: Advancing Cancer Research View all 7 articles

Advancing Precision Medicine in Gliomas Through Single-Cell Sequencing: Unveiling the Complex Tumor Microenvironment

Provisionally accepted
Jinwei Li Jinwei Li 1Yang Zhang Yang Zhang 2Cong Liang Cong Liang 3Yan Xianlei Yan Xianlei 3Xuhui Hui Xuhui Hui 1Quan Liu Quan Liu 3*
  • 1 Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
  • 2 Graduate School, Kunming Medical University, Kunming, Yunnan Province, China
  • 3 Liuzhou Workers Hospital, Liuzhou, Guangxi Zhuang Region, China

The final, formatted version of the article will be published soon.

    Glioblastoma (GBM) displays an infiltrative growth characteristic that recruits neighboring normal cells to facilitate tumor growth, maintenance, and invasion into the brain. While the blood-brain barrier serves as a critical natural defense mechanism for the central nervous system, GBM disrupts this barrier, resulting in the infiltration of macrophages from the peripheral bone marrow and the activation of resident microglia.Recent advancements in single-cell transcriptomics and spatial transcriptomics have refined the categorization of cells within the tumor microenvironment for precise identification. The intricate interactions and influences on cell growth within the tumor microenvironment under multi-omics conditions are succinctly outlined. The factors and mechanisms involving microglia, macrophages, endothelial cells, and T cells that

    Keywords: Glioblastoma, TME, single-cell, GAMs, TAMs

    Received: 06 Mar 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Li, Zhang, Liang, Xianlei, Hui and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Quan Liu, Liuzhou Workers Hospital, Liuzhou, Guangxi Zhuang Region, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.