AUTHOR=Frazzi Raffaele 

TITLE=KLF4 is an epigenetically modulated, context-dependent tumor suppressor

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2024.1392391

DOI=10.3389/fcell.2024.1392391

ISSN=2296-634X

ABSTRACT=<p>The epigenetic layer of regulation has become increasingly relevant in the research focused on tumor suppressors. <italic>KLF4</italic> is a well-described zinc-finger transcription factor, mainly known for its role in the acquisition of cell pluripotency. Here we report and describe the most relevant epigenetic regulation mechanisms that affect <italic>KLF4</italic> expression in tumors. CpG island methylation emerges as the most common mechanism in several tumors including lung adenocarcinoma, hepatocellular carcinoma, non-Hodgkin lymphomas, among others. Further layers of regulation represented by histone methylation and acetylation and by non-coding RNAs are described. Overall, <italic>KLF4</italic> emerges as a crucial target in the fight against cancer.</p>