AUTHOR=Harmych Sarah J. , Tydings Claiborne W. , Meiler Jens , Singh Bhuminder TITLE=Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of basolateral proteins JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=12 YEAR=2024 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2024.1379224 DOI=10.3389/fcell.2024.1379224 ISSN=2296-634X ABSTRACT=

Delivery to the correct membrane domain in polarized epithelial cells is a critical regulatory mechanism for transmembrane proteins. The trafficking of these proteins is directed by short amino acid sequences known as sorting motifs. In six basolaterally-localized proteins lacking the canonical tyrosine- and dileucine-based basolateral sorting motifs, a monoleucine-based sorting motif has been identified. This review will discuss these proteins with an identified monoleucine-based sorting motif, their conserved structural features, as well as the future directions of study for this non-canonical basolateral sorting motif.