The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 12 - 2024 |
doi: 10.3389/fcell.2024.1370717
This article is part of the Research Topic Methods to Develop and Study Animal Cell Degeneration Disorders Resembling Human Pathologies View all 8 articles
A Potential Gateway to Understanding Liver Disease Development: Peripartum Lipid Fluctuations in Dairy Cows
Provisionally accepted
Laura Vogel
1
Markus Güttler
2
Kirsten Berit Theinert
1
Teja Snedec
1
Kristin Reichelt
1*
Fabian Pietsch
1*
Melanie Schären-Bannert
1
Fanny Rachidi
1*
Gabriele Dobeleit
2*
Herbert Fuhrmann
2*
Alexander Starke
1*
Frank Edlich
2*- 1 Department for Ruminants and Swine, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Lower Saxony, Germany
- 2 Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Lower Saxony, Germany
Current lifestyles are leading to a worldwide increase in metabolic liver diseases that favor the development of liver disease. Changes in hepatocytes are caused by altered lipid concentrations, oxidative stress or toxicity by individual lipids. The complexity of the underlying processes and differences of the pathology to proposed rodent models makes the development of an effective targeted therapy difficult. The lipid mobilization that occurs in dairy cows in the postpartum period could be a natural model for the metabolic stress commonly observed in the development of liver diseases. We therefore analyzed lipid patterns of diparous and multiparous cows in the peripartum period. The most striking change in lipid composition is the homogenous increase in palmitoleic acid (C16:1n7) content in all cows around the time of calving, with multiparous cows exhibiting consistently higher C16:1n7 levels by the end of the study. Elevated C16:1n7 levels have a potential key role in the development of non-alcoholic steatohepatitis (NASH) and tumorigenesis in the liver. Changes in C16:1n7, therefore, support the idea that lipid mobilization in dairy cows could serve as model for various liver diseases, such as nonalcoholic fatty liver disease (NAFLD) or NASH development.
Keywords: Lipid Metabolism, Liver disease, NASH, NAFLD, Peripartum Period
Received: 16 Jan 2024; Accepted: 04 Nov 2024.
Copyright: © 2024 Vogel, Güttler, Theinert, Snedec, Reichelt, Pietsch, Schären-Bannert, Rachidi, Dobeleit, Fuhrmann, Starke and Edlich. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kristin Reichelt, Department for Ruminants and Swine, Faculty of Veterinary Medicine, Leipzig University, Leipzig, 04103, Lower Saxony, Germany
Fabian Pietsch, Department for Ruminants and Swine, Faculty of Veterinary Medicine, Leipzig University, Leipzig, 04103, Lower Saxony, Germany
Fanny Rachidi, Department for Ruminants and Swine, Faculty of Veterinary Medicine, Leipzig University, Leipzig, 04103, Lower Saxony, Germany
Gabriele Dobeleit, Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Leipzig University, Leipzig, 04103, Lower Saxony, Germany
Herbert Fuhrmann, Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Leipzig University, Leipzig, 04103, Lower Saxony, Germany
Alexander Starke, Department for Ruminants and Swine, Faculty of Veterinary Medicine, Leipzig University, Leipzig, 04103, Lower Saxony, Germany
Frank Edlich, Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Leipzig University, Leipzig, 04103, Lower Saxony, Germany
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.