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ORIGINAL RESEARCH article

Front. Cell Dev. Biol.
Sec. Morphogenesis and Patterning
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1361485

A Pig Model Exploring the Postnatal Hair Follicle Cycle

Provisionally accepted
Shujuan Li Shujuan Li Quan Zou Quan Zou Yao Jiang Yao Jiang Yi Wang Yi Wang Xiangdong Ding Xiangdong Ding *
  • China Agricultural University, Beijing, China

The final, formatted version of the article will be published soon.

    The hair follicle (HF) is a micro-organ capable of regeneration. A HF cycle consists of an anagen, catagen and telogen. Abnormalities in the HF cycle can lead to many hair disorders such as hair loss. The pig is a good biomedical model, but there are few data on their HF cycle. The aim of this study was to classify the pig HF cycle and determine the feasibility of the pig as an animal model for human HF cycle. We used skin samples from 10 different postnatal (P) days Yorkshire pigs to determine the key time points of the first HF cycle in pig. By morphological observation and detection of markers at different stages, pig HF cycle was classified into three main periods -the first anagen until P45, catagen (P45-P85), telogen (P85-P100), and next anagen (>P100). In addition, we examined the expression of important genes AE15, CD34, Versican, Ki67 et al. related to the HF cycle at different stages of pig HF, indicating that pig and human share similarities in morphology and marker gene expression patterns of HF cycle. Our findings will facilitate the study of HF cycle and offer researchers a suitable model for human hair research.

    Keywords: Hair follicle cycle, anagen, Catagen, telogen, pig model

    Received: 26 Dec 2023; Accepted: 03 Sep 2024.

    Copyright: © 2024 Li, Zou, Jiang, Wang and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiangdong Ding, China Agricultural University, Beijing, China

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