AUTHOR=Jiang Jin-he , Ren Ru-tong , Cheng Yan-jie , Li Xin-xin , Zhang Gui-rong TITLE=Immune cells and RBCs derived from human induced pluripotent stem cells: method, progress, prospective challenges JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=11 YEAR=2024 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1327466 DOI=10.3389/fcell.2023.1327466 ISSN=2296-634X ABSTRACT=
Blood has an important role in the healthcare system, particularly in blood transfusions and immunotherapy. However, the occurrence of outbreaks of infectious diseases worldwide and seasonal fluctuations, blood shortages are becoming a major challenge. Moreover, the narrow specificity of immune cells hinders the widespread application of immune cell therapy. To address this issue, researchers are actively developing strategies for differentiating induced pluripotent stem cells (iPSCs) into blood cells